PROTIDES OF THE BIOLOGICAL FLUIDS

The ProTides Boom.

The masking of nucleoside phosphate and phosphonate groups by an aryl motif and an amino acid ester, nowadays known as the 'ProTide' technology, has proven to be effective in the discovery of nucleotide therapeutics. Indeed, this technology, which was invented by Chris McGuigan in the early 1990s, has inspired the discovery of two FDA-approved antiviral nucleotide drugs, and many more are curre...

The Determination of Thiocyanate in Biological Fluids

The analysis of cannabinoids in biological fluids.

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Cytokine Measurements in Biological Fluids

IT IS now widely accepted that the investigation of cytokine expression during inflammation can provide information about the pathogenesis of disease and help to define key therapeutic targets [1]. These studies have been greatly facilitated by the availability of recombinant human cytokines, essential for the development of specific assays. As assays have become more widely available, rheumato...

Electromembrane extraction from biological fluids.

Electro-assisted extraction of ionic drugs from biological fluids through a supported liquid membrane (SLM) and into an aqueous acceptor solution was recently introduced as a new sample preparation technique termed electromembrane extraction (EME). The applied electrical potential across the SLM has typically been in the range of 1-300 V. Successful extractions have been demonstrated even with ...